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Irresistible Spicy Southern Cheesy Chicken Spaghetti Casserole

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This Spicy Southern Cheesy Chicken Spaghetti Casserole blends tender chicken, spaghetti, creamy soup, and melty cheddar with bold Southern spices. It’s a cozy, crowd-pleasing dish perfect for busy weeknights or family gatherings.

  • Total Time: 45 minutes
  • Yield: 8 servings

Ingredients

  • lbs boneless skinless chicken breasts
  • 8 oz spaghetti
  • 1 cup chopped fresh bell peppers
  • ¼ cup chopped green onions
  • 1 tsp garlic powder
  • ½ tsp cayenne pepper
  • 1 tsp paprika
  • 1 can cream of chicken soup
  • 2 cups shredded sharp cheddar cheese
  • Additional cheese for topping

Instructions

  1. Preheat oven to 350°F (175°C). Grease a 9×13-inch baking dish.
  2. Cook spaghetti according to package instructions, drain, and set aside.
  3. Cook chicken breasts thoroughly, then shred or chop into bite-sized pieces.
  4. In a large skillet, sauté bell peppers until softened. Add garlic powder, cayenne, and paprika. Stir to combine.
  5. Add cream of chicken soup and heat gently until combined with the pepper mixture.
  6. Stir in shredded chicken and cooked spaghetti, mixing until evenly coated.
  7. Transfer mixture to the prepared baking dish. Top with shredded cheddar cheese and extra cheese if desired.
  8. Bake uncovered for 20–25 minutes, or until bubbly and heated through.
  9. Let rest for a few minutes before serving.

Notes

  • Use rotisserie chicken for a quicker version.
  • Add a splash of milk or cream for extra creaminess.
  • For more heat, use jalapeños or spicy Rotel.
  • Make it ahead by assembling the night before and refrigerating until ready to bake.
  • Freezer-friendly for up to 3 months—thaw before reheating.
  • Author: Amelia
  • Prep Time: 20 minutes
  • Cook Time: 25 minutes
  • Category: Dinner, Main Course
  • Method: Baking
  • Cuisine: Southern
  • Diet: Halal

Nutrition

  • Serving Size: 1 portion
  • Calories: 420
  • Sugar: 3g
  • Sodium: 710mg
  • Fat: 24g
  • Saturated Fat: 11g
  • Unsaturated Fat: 10g
  • Trans Fat: 0g
  • Carbohydrates: 27g
  • Fiber: 2g
  • Protein: 25g
  • Cholesterol: 90mg