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The Best Easy Chicken Alfredo Lasagna

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A rich and creamy Chicken Alfredo Lasagna layered with tender chicken, spinach Alfredo sauce, and melted mozzarella. Perfect for cozy dinners, special occasions, or meal prep.

  • Total Time: 1 hour 40 minutes
  • Yield: 12–14 servings

Ingredients

  • For the Chicken:
  • 400500g chicken tenders or breast
  • Salt, to taste
  • Black pepper, to taste
  • Cayenne pepper, to taste
  • Garlic powder, to taste
  • Italian seasoning
  • Olive oil
  • For the Spinach Alfredo Sauce:
  • Unsalted butter
  • 1 onion, finely chopped
  • 23 garlic cloves, minced
  • Salt and pepper to taste
  • Chili flakes, to taste
  • Italian seasoning
  • 2 tablespoons all-purpose flour
  • 1½ cups whole milk
  • 1 cup heavy cream (or more milk)
  • 1 cup grated Parmesan cheese
  • 1 cup chopped spinach
  • For Assembly:
  • 1415 lasagna sheets (regular or oven-ready)
  • 34 cups shredded mozzarella cheese
  • Fresh parsley, chopped (for garnish)

Instructions

  1. Cook lasagna sheets until al dente or prep oven-ready sheets as per package instructions. Lightly oil to prevent sticking.
  2. Season chicken with spices and olive oil. Sear in skillet for about 5 minutes per side until cooked through. Rest and chop into small chunks.
  3. In a non-stick pan, melt butter and sauté onion until soft. Add garlic and spices. Stir in flour and cook briefly.
  4. Whisk in milk and cream, cook until slightly thickened. Stir in spinach and Parmesan off heat. Adjust seasoning to taste.
  5. Preheat oven to 375°F. In a 9×13″ dish, spread a little sauce. Layer pasta sheets, sauce, chicken, and mozzarella. Repeat layers 3 times.
  6. Top with final pasta layer, sauce, and remaining mozzarella. Tent with foil and bake 40 minutes. Broil 2–3 minutes for golden top.
  7. Let rest 15 minutes before slicing. Garnish with fresh parsley.

Notes

  • Add mushrooms for extra flavor or use roasted vegetables for a vegetarian version.
  • Swap cheeses like provolone or gouda for variety.
  • Jarred Alfredo sauce can be used in a pinch—enhance with spinach and seasoning.
  • Prepare ahead and refrigerate; bake just before serving.
  • Freeze baked or unbaked lasagna for up to 2 months.
  • Author: Amelia
  • Prep Time: 1 hour
  • Cook Time: 40 minutes
  • Category: Main Dish
  • Method: Baking
  • Cuisine: Italian-American
  • Diet: Halal

Nutrition

  • Serving Size: 1 slice
  • Calories: 480
  • Sugar: 4g
  • Sodium: 620mg
  • Fat: 28g
  • Saturated Fat: 15g
  • Unsaturated Fat: 10g
  • Trans Fat: 0g
  • Carbohydrates: 30g
  • Fiber: 2g
  • Protein: 28g
  • Cholesterol: 115mg